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Banga, Harmanjit Singh
- Amelioration of Bleomycin-Induced Acute Lung Injury and Epithelial-Mesenchymal Transition by Baicalein in Mice
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Authors
Affiliations
1 Department of Veterinary Pathology, and Animal Disease Research Centre, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, IN
2 Animal Disease Research Centre, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, IN
1 Department of Veterinary Pathology, and Animal Disease Research Centre, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, IN
2 Animal Disease Research Centre, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, IN
Source
Current Science, Vol 119, No 6 (2020), Pagination: 962-972Abstract
During lung fibrosis, acute pulmonary inflammation and epithelial–mesenchymal transition (EMT) play important roles. The present study analyses the ameliorative effect of baicalein, a bioactive flavonoid present in the dry ischolar_mains of Scutellaria baicalensis Georgi, on bleomycin-induced acute lung injury and subsequent EMT. Mice received a single intratracheal instillation of saline containing bleomycin @1 mg/kg body wt. Baicalein in different doses (0.1, 1.0, 10 mg/kg) was given intraperitoneally daily for one week. Pulmonary inflammation and EMT parameters were evaluated. Baicalein significantly attenuated bleomycin-induced pulmonary inflammatory and structural changes. Thus, treatment with baicalein ameliorates bleomycininduced acute inflammation and subsequent early stage of EMT.Keywords
Acute Lung Injury, Baicalein, Bleomycin, Epithelial-Mesenchymal Transition, Mice.Full Text
References
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